Job Description

Principal Scientist position in materials science at Pfizer's Groton, Connecticut facility, focusing on solid-form and particle characterization of pharmaceutical compounds. The role involves leading multidisciplinary teams to advance drug molecules from discovery through commercialization using advanced analytical and computational methods.

Responsibilities

• Lead multidisciplinary project teams as Materials Science Lead to define solid-form and particle design strategies
• Conduct crystallization screening and evaluation of drug candidate forms for chemical manufacturing compatibility
• Perform solid-state characterization using X-ray diffraction, spectroscopy, thermal analysis, and particle sizing techniques
• Apply computational approaches to design experiments and predict crystalline properties of drug substances
• Oversee external laboratory studies and mentor internal scientists on materials science experimentation

Requirements

• Ph.D. in Chemistry, Engineering, Materials Science, Pharmaceutics or related field with 5+ years materials science industry experience, OR Master's degree with 10+ years relevant experience
• Demonstrated expertise in small molecule crystallization and solid-state characterization techniques
• Experience preparing regulatory submissions and responding to queries on solid form and particle characterization
• Strong data analysis capabilities and statistical knowledge
• Excellent oral and written communication skills
• Proficiency with computational software for predicting pharmaceutical material properties
• Knowledge of powder and surface characterization methods for pharmaceutical applications

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